Poo transplants beat antibiotics for treating C. diff superbug

Treating recurrent Clostridioides difficile (CDI) with fecal microbiota transplantation (FMT) increased survival by nearly 30 percent, cut length of hospital stay in half, and reduced the risk of sepsis by nearly four times compared to treating with antibiotics. Findings from a prospective cohort study are published in Annals of Internal Medicine.

Recurrent CDI is often antibiotic-resistant and is associated with life-threatening complications, including bloodstream infections. A substantial proportion of patients with CDI are likely to develop bloodstream infections, most of which are caused by intestinal microbes and lead to death in more than 50 percent of patients. Fecal microbiota transplantation (FMT) is more effective than antibiotics in treating recurrent CDI, but its efficacy in preventing CDI-related BSI is uncertain.

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